Development of bioadhesive chitosan gels for topical delivery of lidocaine
نویسندگان
چکیده
منابع مشابه
Development of Bioadhesive Transdermal Bupivacaine Gels for Enhanced Local Anesthetic Action
Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...
متن کاملDevelopment of Bioadhesive Transdermal Bupivacaine Gels for Enhanced Local Anesthetic Action
Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...
متن کاملdevelopment of cross-linked chitosan films for oral mucosal delivery of lidocaine
lidocaine (lc) is a local anesthetic agent. the aim of this study was to prolong the anesthetic effect of this drug in the oral cavity in the treatment of oral mucositis. films of lc were prepared with three different molecular weights (mw) of chitosan in three different concentrations (1-3%) and were then cross-linked by solvent casting evaporation method with tripolyphosphate penta sodium sal...
متن کاملDevelopment of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System
Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 3(2) full factorial design was applied to optimize the concentration of chitosan and HPMC. T...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2006
ISSN: 0036-8709
DOI: 10.3797/scipharm.2006.74.209